INTRODUCTION Physicians, pharmacists and patients generally do not appreciate the use of suppositories although this dosage fomi has many clinical advantages, similarly the drug release from the suppositories bases and factors influencing the drug release have not been fully established. 1.2 Relationship between dossier specifications and the Pharmacopoeia Home Suppository Bases. water/base partition coefficient. Important characteristics for suppositories include (1) hardness (for proper handling and delivery), (2) shape (for comfortable insertion and retention), (3) solubilization of drug in suppository matrix, and (4) rapid melting after application. 15 -25oC and melts at body temp (for oil based suppositories) • Amorphous, smooth, non-irritating vehicle • Medicinally inert without side effects Types: Oleaginous (fatty/oily) bases (lipophilic) Theobroma Oil (cocoa butter) & synthetic triglyceride mixtures o Water soluble bases (hydrophilic) Search for more papers by this author. Synonyms for Suppository bases in Free Thesaurus. We offer a wide range of suppository bases. • A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to the surrounding aqueous fluids than a hydrophilic substance in a fatty base. -Emulsified Theobroma oil maybe used as base when large quantities of aqueous solutions are to be incorporated. Witepsol®H15 is an NF grade, small pastille form suppository base comprised of glycerides from vegetable origins with a long history of use with a wide range of APIs. Table 1: Evaluation of the partitioning of C31G between various suppository bases/pH 8 buffer and chloroform/pH 8 buffer (n = 3) Measurement of gelation temperature. are preferred for vaginal and urethral supposiories. University of Tennessee School of Pharmacy Memphis, Tenn. Graduate student in Hospital Pharmacy, University of Tennessee School of Pharmacy. There are three types of suppositories, each to insert into a different orifice: Rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male [Stability of drugs in lyophilic suppository bases. 1.1.1. What is the main prereq for a suppository base? Gently but firmly, push the suppository past the sphincter. Boll Chim Farm. Antonyms for Suppository bases. A suppository can be introduced into any absorbent orifice of the body,such as the vagina. Insert the suppository into the rectum, narrow end first. The influence of suppository bases upon the rectal absorption of acetylsalicylic acid. 1. Types of suppository bases by Hadeer Zedan 1. Liquid suppository bases were kept at 4°C prior to use. A suppository is a pill or medication that is inserted through the rectal area of the body. Determine the density factor of a drug in polyethylene glycol suppositories. 1973 Feb;112(2):116-33. 4- Saponification value ; The number of milligrams of potassium hydroxide required to neutralize the free acids and to saponify the esters contained in 1 gm of fat is an indication of the type of glyceride (mono- or tri-) as well as the amount of glyceride present. List and describe a variety of suppository bases. They are chemically stable, nonirritating, miscible with water and mucous secretions, and can be formulated, either by molding or compression, in a wide range of hardness and melting point. What are synonyms for Suppository bases? 2.3. Suppository bases play an important role in the release of medication they hold and the availability of the drug. Prepare suppositories by the fusion (molding) technique. Describe three (3) methods of suppository preparation. Oleaginous (fatty or hydrophobic) bases. Oily bases or oleoginous bases 1.1. A suppository is another way to deliver a drug. but soften, melt or dissolve readily at body temp; so … SUPPOSITORY BASES: Solid form at room temp. A problem that both compounders and patients face is the burdensome process of removing suppositories from outdated molds, whether they’re from bulky metal trays or the peel-away plastic suppository shells. (C) VAGINAL SUPPOSITORY It is in oviform shape. Advantages: 1. The six general classes of suppository bases identified by the USP are described here. There seems to be little or no work done with such compounds as plastics, synthetic resins, and other similar condensation products. For adults, push it … selection of suppository bases depends on. 1974;31(5):651-6. Standard suppository molds offer challenges to compounders, because they are time consuming both to use and to clean. Wecobee bases: triglycerides derived from coconutoil. Oleaginous bases include theobroma oil (also called cocoa butter) and synthetic triglyceride mixtures. V. Identification of products of ethionamide decay isolated from suppositories]. Backed by vast experience, we manufacture and supply a wide gamut of Suppository Bases. Suppository bases may be classified according to their composition and physical properties: 1- Oleaginous (fatty) bases 2- Water soluble or miscible bases 37 3- Miscellaneous Bases Specifications of suppository bases 1- Origin and chemical composition The source of origin (i.e. the release fo a drug from a fatty, lipophilic suppository base to the aqueous medium in the rectum depends on the _____ of the drug. A suppository base must remain solid at room temp. The sphincter is the muscular opening of the rectum. Examples of Macrogol bases: I II III IV Macrogol 400 Macrogol 1000 Macrogol 1540 Macrogol 4000 Macrogol 6000 Water - - - 33 47 20 - - 33 - 47 20 20 - 33 - 47 - - 75 - 25 - - By choosing a suitable combination a suppository base with the desired characteristics can be prepared. It is contains the drugs which are used in treatment of the infections of female genitourinary tract and meant for contraception. Suppository bases can be classified as according to their composition and physical properties. Suitable for both rectal and vaginal use. • Water soluble bases—for example, polyethylene glycols— that dissolve in the anorectal fluids release for absorption 4 words related to suppository: medicament, medication, medicinal drug, medicine. These are made with best quality material and have sodium stearate as a component. A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects. Supposi-Plex™ V33 Suppository Base Supposi-Plex V33 is a pellet form, easy to use compounding suppository base that is derived from vegetable and fatty alcohol origins. A 20-ml transparent vial containing a magnetic bar and 10 g of liquid suppository base was placed in a low-temperature thermostat water bath (Heto, Scandinavia). Anthony F. Cacchillo. 21 Specifications of suppository bases It's a small, round or cone-shaped object that you put in your body, often into your bottom. 1. Fat-type suppository bases can be produced from a variety of vegetable oils, such as coconut or palm kernel, which are modified by esterification, hydrogenation, and fractionation to obtain products of varying composition and melting temperatures (e.g., Hydrogenated Vegetable Oil and Hard Fat).These products can be so designed as to reduce rancidity. bases also have low hydroxyl values (15 < 6 < 6) when compared to others, it is possible to explain the high release percentage of the active substance C31G from the vaginal suppositories prepared using these bases. Describe the proper formulation, packaging, and administration of suppository bases. It is contains the combination of polyethylene glycol of different molecular weights as suppository bases. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, mixtures of polyethylene glycols of various molecular weights, … Suppository base excipients are used in the manufacture of suppositories (for rectal administration) and pessaries (for vaginal administration). [Determination of the course of melting and solidification of suppository bases]. Witepsol bases: triglycerides of saturated fatty acids C12–C18, their melting ranges vary from 32 - 42 oC . [Article in Italian] They are used commercially in numerous applications, including as surfactants, in foods, in cosmetics, in pharmaceutics, in biomedicine, as dispersing agents, as solvents, in ointments, in suppository bases, as tablet excipients, and as laxatives. fatty bases. Emulsified cocoa butter. Some properties of fatty suppository bases Acid content Hydroxyl number Iodine number Cocoa butter <5 0 34-38 Semi-synthetic fatty bases … are preferred for rectal suppositories. Solubility: Witepsol®H15 is readily soluble in diethylether, toluene and … A review of the literature on suppository bases shows that much work has been done on fattype bases such as cocoa butter.Some investigations have been made on water‐soluble and emulsion type bases. At least those aspects considered to be critical should be the object of specifications routinely verified. PEG bases. suppository bases in a sentence - Use "suppository bases" in a sentence 1. Identify the best product for your purpose and ask the related technical sheet to our team which will be pleased to help you. It is about 3-5g in weight. -5% Glyceryl monostearate, 10% Lanette wax, 2_3% cetyl alcohol &4% bees wax is recommended for emulsified Theobroma oil. Page 7 8. Suppository Bases Sort by Sort by Show 24 36 48 View as from $32.00. Acta Pol Pharm. An appropriate specification for each aspect of quality studied during the phase of development and during the validation of the manufacturing process should be determined. Suppository bases. Specifications of suppository bases. Polyethylene Glycol Polymers have received much attention as suppository bases in recent years because they possess many desirable properties. entirely natural or synthetic or modified natural). Triglyceride mixtures School of Pharmacy are made with best quality material and have sodium stearate as component. Rectal area of the infections of female genitourinary tract and meant for contraception by... And physical properties Show 24 36 48 View as from $ 32.00 Tenn. Graduate student in Hospital Pharmacy, of! Acids C12–C18, their melting ranges vary from 32 - 42 oC meant contraception. Is readily soluble in diethylether, toluene and … ( C ) VAGINAL suppository it is in oviform shape (! 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